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Q&A: Will Lisybin Help a Dog With Elevated Liver Enzymes?

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Dr. Mark is a veterinarian. He has been working with dogs for more than 40 years.

Most senior dogs with high liver values but no symptoms are not treated.

Most senior dogs with high liver values but no symptoms are not treated.

Will Medication Keep My Dog With High Liver Enzymes Healthy?

"My 10-year-old Labrador, Mixy, has started to show very high liver enzymes in her liver function test. Do you see anything alarming in her LFT, KFT and CBC report? Mixy is currently on a medication called Lisybin (S-Adenosylmethionine and Silybin A+B Tablets). Will these be enough to keep her healthy?" —Shwetadri

Elevated Liver Enzymes in Senior Dogs

Most senior dogs with high liver values but no clinical signs are not treated. In a study of healthy senior dogs, elevated liver enzymes with no signs was common. Alkaline phosphatase (ALP) was high in about 27%. (1)

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Mixy's levels are high but not alarming. Her bilirubin levels and albumin levels are still normal and she does not have jaundice or other signs of liver disease. If she had jaundice or other symptoms, a biopsy of the liver would be in order to find out if there was anything else you need to do. Since she is still okay, the medication that you are using is appropriate and will not harm her.

If she does develop jaundice despite the medications you are giving, there are other alternatives. For the time being, it is fine to keep her on the Lisybin at the dose your regular veterinarian recommends.


(1) Willems A, Paepe D, Marynissen S, Smets P, Van de Maele I, Picavet P, Duchateau L, Daminet S. Results of Screening of Apparently Healthy Senior and Geriatric Dogs. J Vet Intern Med. 2017 Jan;31(1):81-92.

This article is not meant to substitute for diagnosis, prognosis, treatment, prescription, or formal and individualized advice from your veterinarian. Animals exhibiting signs and symptoms of distress should be seen by a veterinarian immediately.

© 2022 Dr Mark

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