How to Give a Cat Comfortis Flea Pills

A cat with fleas feels uncomfortable.  If you live in a warmer climate or your cat goes in and out, you may have to work extra hard to fight them.
A cat with fleas feels uncomfortable. If you live in a warmer climate or your cat goes in and out, you may have to work extra hard to fight them. | Source

I have been fighting a flea problem with my indoor cats for several weeks.

All but one of my indoor cats seem to be responding to topicals such as Advantage or Frontline. However, they would still have a few fleas on them in the evening when I would comb them.

But one cat was still having a flea party despite me trying two kinds of topicals and flea combing him every day.

I went in to talk to my vet's office and they recommended Comfortis (which I already give to my dog).

Here is my review of Comfortis and how to give your cat that large pill with relative ease.

The results of Comfortis make it worth the trouble.

Where to Get Comfortis for Cats

Comfortis is a 30 day pill that gets rid of fleas by killing the adults and breaking the flea cycle. It was approved in August 2012 for use in cats but word has been slow to get out.

You can only get Comfortis from an approved vet office although some may offer an online prescription.

If your pet is up-to-date on his or her shots, you should have no problem getting the pill.

How Does It Work?

Comfortis is made from a chemical called spinosad which actually originates in soil.

Spinosad attacks the nervous system of the flea and then kills it.

When a flea bites your cat, it gets a dose of the spinosad.

One of the ways it helps control fleas is by stopping the reproductive cycle. The adult fleas can't live long enough to reproduce.

Correct Dose For Cats

Cat Weight
Tablet Size
2 to 4 pounds
90 mg
4.1 to 6 pounds
140 mg
6.1 to 12 pounds
270 mg
12.1 to 24 pounds
560 mg
Over 24 pounds
Combine above pills to reach proper dosage to weight ratio.
Some packaging still just has dog weights. Just find the pill size and correspond it with your cat's weight.
Sometimes you need something extra to break the flea cycle.  Comfortis for cats might be the answer.
Sometimes you need something extra to break the flea cycle. Comfortis for cats might be the answer. | Source

Ways to Give Your Cat Comfortis

Many cat owners are hesitant to give their cat Comfortis because of the size of the pill and because it is imperative that the pill be given with food.

I've found a simple solution to take care of both aspects.

How To Give A Cat Comfortis
1. Get a few tablespoons of canned food and place in a bowl.
Make sure it is an easy to digest food
2. Break the Comfortis into 2 or 4 pieces.
The pills are large if your cat is over 12 pounds. They might be able to swallow the smaller one if they are under 12 pounds.
3. Place the cat in your lap, on its back with the spine pressed against your stomach.
You can wrap the cat in a towel with only his or her head sticking out if they tend to fight being handled.
4. Give the cat some food by letting him or her lick it off your finger.
If the cat doesn't want to take it, simply put the food on your finger and wipe it on the roof of their mouth. He or she will be forced to eat it.
5. Give the cat a piece of the pill by either hiding it in their food or gently prying open their mouth and dropping it towards the back of their throat.
To open a stubborn cat's mouth, take your thumb and first finger and place one on either side of the mouth, at the jaw. Press gently to cause the jaw to unhinge then drop the pill as far back in the throat as possible.
6. Give all the pieces of the pill and then follow with the rest of the food.
Make sure to not overfeed the cat. The goal is to line the stomach and keep the cat from throwing up the pill. Guidelines recommend watching your cat for an hour to make sure he or she does not vomit. If they do puke after the hour, it is okay because the pill will already be absorbed. If they vomit before the hour is up, you may want to redose or try a different flea control.

Comfortis for Cats Can Be Used with Other Topicals

When you get Comfortis for your cat, it is important to talk to your vet about the possibility of using it with other medications your pet might be on.

Since Comfortis just kills the adult fleas, I also wanted to be able to use a topical such as Frontline or Advantage in order to help inhibit the other life stages of the flea such as the egg and larva.

My vet said that it is safe to give a topical and Comfortis together because they work differently.

Since I am fighting fleas because of being in a southern state and because of the lack of a freezing winter, I have opted to continue topical use along with the Comfortis.

Topicals were mostly working but needed that extra push. This pill was what I needed to achieve a flea-free pet once again.

You can buy Comfortis as a single dose, making it an economical choice if you are trying it out.
You can buy Comfortis as a single dose, making it an economical choice if you are trying it out. | Source

Final Thoughts on Comfortis for Cats and Its Effectiveness

Take Aways

  • One of my cats was not responding well to topicals.
  • The vet said that some cats' skin and coat chemistry don't spread the flea medication as well.
  • I was afraid that Comfortis would make my cat sick when I gave it to him but it didn't.
  • Following the steps listed allowed me to insure my cat took the pill with food, and none of the cats that I gave it to had an adverse reaction including a 14 year old long-haired tabby.

If you seem to have super fleas or have tried topicals and they have failed, you might consider trying Comfortis, at least for a few months, in order to break the flea cycle.

A Vet Recommends Comfortis

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Comments 27 comments

DJ6ta 3 years ago

I have been doing the Comfortis pill thing with my cats for about a year now and it is murder to my arms every time. However, I just found the best way to do this. I start by trimming the claws, then, after that trauma has had about 10 minutes to wear off, I begin to crush the pill into powder form. The dust is very water-soluble so it mixes well if added into a medication syringe. I then add some juice from some canned cat food with the water and crushed pill inside the syringe. I bundle the cat in a blanket up to the neck and give the medication a few squirts at a time until it’s all gone. Despite the prep time, this process is a lot faster and it is less violent to the cats and to me. I then let them share the canned food I opened up earlier and they are set for another month. I hope this helps anyone who has a 30-pound cat like me and has to give them one of those horse pill sized Comforis doses.

LCDWriter profile image

LCDWriter 3 years ago from Florida Author

That's another fantastic way to do this. Do you give them food first? I found that my cats had to have some food first or they would puke it back up.

Wow. A 30 pound cat is quite a big one!

Comfortis really is good stuff! We had really bad fleas and they are all gone!

DJ6ta 3 years ago

I gave them their food earlier and I gave them food immediately afterwards so they can get that terrible taste our of their mouths. Yep, 30 pound cat, he is a big boy but is also the biggest cuddle bug I have ever seen, lol. Comfortis is really good stuff, I tried every topical treatment I could think of and nothing ever worked good enough to keep the tape worms away. I used Comfortis for my pitbulls way before it was OK for cat use, but even then I could see that this was going to be the best flea solution.

LCDWriter profile image

LCDWriter 3 years ago from Florida Author

Thank you so much for sharing this. I'm keeping your ideas for use with my own cats. That would work great for a variety of pills!

dj6ta 3 years ago

You are very welcome. I can imagine this would work for many other pills as well. I would caution though, some pills may have a coating on the outside that isn't all that water-soluable.

glh 3 years ago

I have a 12 pound cat. The first time I gave him the Comfortis pill, he threw it up within about an hour. I waited two months and tried again. This time I split the pill into 4 pieces. I gave him 1/4 of the pill on 4 successive days. It seem to work. No more getting sick and fleas don't seem to be a problem. Live in FL which has had mild winters lately so fleas have been really bad the past two years.

LCDWriter profile image

LCDWriter 3 years ago from Florida Author

I really like this idea. The only concern I would have is if they still get full strength protection. I'll ask my vet next time I talk to her.

LCDWriter profile image

LCDWriter 3 years ago from Florida Author

Another way to get the pill down is to give them part of it, give them some food, give them a bit more and so on. Especially if they are a larger cat and need a bigger pill. I just gave my biggest cat his monthly Comfortis. Now he's pouting behind my desk. :-/

JAX 2 years ago

Can you just put in in their mouth without him chewing it??

JAX in PA 2 years ago

He didn't give me a problem at all while swallowing it it just effective??? Please let me know

LCDWriter profile image

LCDWriter 2 years ago from Florida Author

I think it should be fine. I would sometimes break it up and put it in pill pockets so it should digest. Hope it works!

YSal 17 months ago

My cat started scratching like crazy as soon as the fleas were dying. Is that normal?

LCDWriter profile image

LCDWriter 17 months ago from Florida Author

Yes. The fleas get active as they are dying.

DzyMsLizzy profile image

DzyMsLizzy 17 months ago from Oakley, CA

I have been accidentally bitten by trying to drop in a pill after prying open a cats mouth, as they fight it. They are not trying to bite you on purpose; they are just making chomping motions trying to spit out the pill.

You can get a "piller" or "pill gun" from the vet that will put the pill far enough back in the mouth while keeping your fingers out of range.

Voted up.

jed 12 months ago

I give my cat comfortis once a month as she murders everyday and tends to scat her ears all the time. I have found the long meat treat sticks fabulous, all you need to do is give her a piece to get her juices going and then break the tablet into 4 pieces and put in a piece of the treat meat stick. This is quite flexible so you can squish it around the pill and she eats every bit, every time. Try it , it definately works.

gators2film 10 months ago

My 12 lb Cat has flea allergy,I've tried everything from shots and Advantix. Changed Vets,and He put him on Comfortis about a year ago and my boy has had NO problems since. Its hard to give it to him,so I just take him to my Vet monthly and they give it to him and only charge for the pill. Great Vet and great product

rusty 5 months ago

Cant get rid of fleas.....comfortis twice. Nothing works?

LCDWriter profile image

LCDWriter 5 months ago from Florida Author

You are likely infested somewhere in the bedding or living area where the cat lives. If it is outside, you may want to call a pest control company to come treat the yard. If inside you can do the same. Also, wash all bedding and vacuum daily. Keep using flea medication. Flea eggs can last many months so it may take some time to finally get the last of the live flea eggs hatched and killed. Hang in there!

romaneo789 4 months ago

I don't know if I tricked my cat by giving her a bunch of crunchy treats before and after, not to mention she eats mostly dry food, but I just offered her the pill and she ate it like it was a treat... They are labeled chew-able right? Has anyone else tried this?

katie 3 months ago

I've been using Comfortis for about a year after a bad flea infestation and the topicals just weren't working. We haven't had any more fleas! The first time, the cat took it like a treat. We didn't have to trick him or anything. The second and third time, it took a pill pocket to disguise the pill. The fourth time, he absolutely refused, so I took him to the vet. Now, I take him to the vet every month to get his pill. They don't charge to administer it!

It's tough because he has to take it with food, so as soon as we get back from the vet, I feed him. I try to get morning appointments and don't feed him until after so that he's hungry. One time, he threw up about an hour after getting the pill. To keep him from throwing up for the first hour, I spend an hour petting him and playing with him so he's distracted if he starts getting nauseous. The manufacturer's directions say that he needs a re-dose if he throws up within an hour, so I figure it's safe after an hour. So far, following the cat around for an hour has worked to keep him from throwing up!

Lisa Loudermilk 3 months ago

If you only give your cat half of the pill will it still help with the flees?

LCDWriter profile image

LCDWriter 2 months ago from Florida Author

You should follow the dosage-per-weight recommendation. It would depend on the size of the cat.

LCDWriter profile image

LCDWriter 2 months ago from Florida Author

This is great advice!

kathy 7 weeks ago

I have to grind the pill into powder and add it to her food. She will refuse to eat it - I leave it for several days sometimes. When I add the old mixture to new food - she is so hungry she will eat the whole mixture. My questions: will comfort still work as prescribed?

LCDWriter profile image

LCDWriter 7 weeks ago from Florida Author


I would assume that would work. Have you talked to your vet about her refusal to eat it? Is there something that she loves to eat?

Joan 2 weeks ago

I delayed giving my cat Comfortis because of the size of the pill. She is about 5kg (11lb). A friend recommended squashing a quarter tablet into a small lump of cheddar cheese, and as she LOVES cheese, I tried that. It worked for two quarter tablets, then she spat it out. I had some left over chicken, which she also loves, so I gave her a couple of pieces, then squashed the other two pieces of Comfortis into some chicken, which I fed her by hand. She ate it with no trouble, and I gave her some food afterwards. She has had no side effects, and was already scratching a lot less the next morning.

LCDWriter profile image

LCDWriter 5 hours ago from Florida Author

Comfortis is really amazing. But yes, sometimes tricking the cat is the best option. Some cats like the pill pockets (and see those as treats) so that might be another option.

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