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Canine Cancer: New, Inexpensive Treatment Prolongs Life for Dogs with Hemangiosarcoma Tumors

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A Common Canine Cancer

Hemangiosarcoma is a relatively common canine cancer that affects 6-8% of all dogs in the United States. As dogs tolerate the tumors well until the late stages of the disease, the prognosis following diagnosis is poor. The average life expectancy following surgical intervention is 180 days. Chemotherapy in addition to surgery, the current standard of care, extends the average dog’s life a mere additional 180 days. Research is underway at several veterinary medical facilities to find a means of early diagnosis and treatment for this fatal cancer.

While researchers at the University of Minnesota have developed a promising line of research involving stem cells; the researchers at University of Pennsylvania have investigated a mushroom compound that can significantly extend the lives of dogs suffering from hemangiosarcoma. Is it possible that they have discovered a treatment that is relatively inexpensive, with no side effects and does not require a prescription?

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Hemangiosarcoma Tumors in Dogs

Hemangiosarcoma is termed an indolent cancer. In the initial stages the cancer develops very slowly, asymptomatically and painlessly. The most common primary sites of the tumors are the spleen, the right atrium of the heart and the tissue beneath the skin. The tumors themselves are vascular in nature. As they grow, they attempt to develop their own blood vessels. However the blood vessels are of inferior quality and malformed. Over time they begin to leak and clot, causing blood loss into the abdominal cavity, heart sac and subcutaneously.

Dogs with hemangiosarcoma may occasionally appear lethargic or apathetic, but as the body quickly reabsorbs the lost blood, they bounce back again. As the tumors grow, they shed cells into the blood stream; eventually the tumors themselves rupture. Typically, by the time of diagnosis, the cancer has already aggressively metastasized to the lungs, liver and intestines.

Primary Tumor Sites

  • Approximately 50% of hemangiosarcoma tumors originate in the spleen
  • 35% of tumors orginate in the heart, liver, kidneys, muscle or bone.
  • 15% of tumors develop on or under the skin.

Current Treatment for Dogs with Hemangiosarcoma

Splenetic and subcutaneous tumors are more readily treatable. The current standard of care is to remove the tumor surgically, and then to treat with chemotherapy. As most universities and veterinary practices do not perform open heart surgery on dogs, there is little that can be done for atrial tumors.

The hemangiosarcoma tumors do not respond well to chemotherapy, adding on average just 180 days to the dog’s lifespan, while at the same time reducing the quality of the extended life. Many owners opt not to treat their dogs, given the poor prognosis resulting from these expensive treatments.

Turkey-tail Fungus aka the Yunzhi Mushroom

Courtesy of Wallwork Family Pages
Courtesy of Wallwork Family Pages | Source

The Number One Holistic Cancer Fighter

The Coriolus Versicolor mushroom, known commonly as the Yunzhi mushroom or the Turkey-tail mushroom, has been used in traditional Chinese medicine for over 2,000 years. Chinese medical practitioners have prized the Yunzhi for its healing and energizing properties. As interest in holistic approaches to medicine have increased over the last two decades, Western researchers have begun studying this mushroom as a possible cancer fighter in humans and canines alike. Much of the research has focused on a compound found within the mushroom, polysaccharopeptide, or PSP.

Occurrence of Cancer in Dogs

Have you had a dog diagnosed with cancer?

  • 1% No
  • 9% Yes, Lymphoma
  • 70% Yes, Hemangiosarcoms
  • 7% Yes, Osteosarcoma
  • 12% Yes, another cancer or unknown cancer
1608 people have voted in this poll.

Yunzhi Mushroom Results in Human Cancer Trials

Dr. Silva Couto and his associates mounted a year long clinical trial examining the effects of Yunzhi mushroom supplementation on patients with Human Papillomavirus (HPV). The findings were impressive, “Coriolus supplementation demonstrated a 72 percent regression rate in lesions compared to 47.5 percent without supplementation, and a 90 percent regression rate in the high risk HPV virus sub-types compared to 8.5 percent without.”

In another study Japanese researchers tested 185 people with lung cancer at various stages of progression of the disease who were receiving radiation treatment. Doctors found those who also took the Yunzhi based supplement showed the best tumor shrinkage and the best survival rate. A similar study of stomach cancer patients produced comparable results.

The bottom line - those who received Yunzhi based supplement survived significantly longer, felt better and had fewer side effects.

The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog's Life Quality and Longevity
The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog's Life Quality and Longevity

The comprehensive guide to understanding your best options in canine cancer treatment, given your dog and your own personal set of circumstances.

Voted one of the Best Books of 2014, this gives pet owners a step-by-step guide to the best practices to help your pet overcome canine cancer.

 
Between 60-80% of all golden retrievers will die from some form of cancer
Between 60-80% of all golden retrievers will die from some form of cancer

Yunzhi Supplements and the Treatment of Cancer in Dogs

In the wake of these impressive results, researchers at U Penn mounted a study of the effects of the Yunzhi supplement, I’m Yunity, on Hemangiosarcoma in dogs. I’m-Yunity is a formulation of PSP which can easily be purchased online. The study was funded by Chinese Medicine Holding LTD. and released in September 2012.

In this study, fifteen dogs that had been diagnosed with naturally occurring hemangiosarcoma participated in the trial. Dividing the subjects into three groups of five, each group received a different dose of I’m Yunity— 25, 50 or 100 mg/kg/day — of I’m-Yunity. Owners were able to treat their animals at home with the supplement, and to return to U Penn on a monthly basis for blood samples and ultrasounds to determine the extent that tumors had developed or spread in the dogs’ bodies.

Dog's Lives Extended with No Side Effects

The results astonished the researchers. “We were shocked,” Cimino Brown of Penn State said. “Prior to this, the longest reported median survival time of dogs with hemangiosarcoma of the spleen that underwent no further treatment was 86 days. We had dogs that lived beyond a year with nothing other than this mushroom as treatment.”

Better yet, the dogs undergoing treatment with I’m Yunity demonstrated no negative side effects. The dogs’ lives were being extended while still maintaining a good quality of life. While dogs receiving the highest dosage, 100 mg/day, had the longest median survival time, it was noted that the difference in survival times between dosages was not statistically significant.

While the PSP supplement, I’m-Yunity, has been shown to extend life, it has not been labeled a cure for hemangiosarcoma. The researchers at Penn State intend to investigate the effects of PSP on dogs with hemangiosarcoma in two future studies. At the very least the PSP supplement may be able to extend dogs’ lives long enough for other cures to come to fruition. The stem cell research being conducted at the University of Minnesota has produced some promising results.

Alternatives to I'm Yunity

While the researchers used I'm Yunity as their brand of Turkey Tail Mushroom extract, many other manufactures exist. If money is a concern, you may want to look at other manufacturers that provide the extract in high dose capsules, at substantially lower costs. The least expensive one we found was made by Swanson Superior Herbs, however countless others exist.

Inexpensive Alternative to I'm Yunity

Swanson Turkey Tail Mushroom 500 mg 120 Caps
Swanson Turkey Tail Mushroom 500 mg 120 Caps

This product from Swanson contains 120 - 500 mg capsules for under twelve dollars. For a 60 pound dog this would be a 24 day supply of the turkey tail mushroom extract.

 

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43 comments

epbooks profile image

epbooks 3 years ago from Las Vegas, NV

I've had two dogs that have come down with cancer; lymphoma and osteosarcoma. It's so prevalent in golden retrievers. I began making bracelets and donating to we are the cure- canine cancer research. Thanks for posting this as many people are not even aware that dogs get cancer!


reviewstop profile image

reviewstop 3 years ago from Spain

I avoid having pets because I think I will be very sad if something bad happens to them.


Solaras profile image

Solaras 3 years ago Author

Thanks for reading epbooks and reviewstop. I lost my favorite dog ever to hemangiosarcoma. I was devastated and still am; but loss is part of life. I have some of her puppies, and they have lived past her age of diagnosis, but I still worry about them. I am glad to see they are working on a ways to alleviate the suffering and hopefully will find a cure soon. My Kiri was only 4.5 years old. Certainly too young for cancer.


Kim 11 months ago

Thanks for the article. I lost my sweet boy to hemangiosarcoma 1 month ago. In wish I'd realized the benefit of I'munity when he was diagnosed. Perhaps he'd still be with us.

One thing I think you have in error is the use of the word "inexpensive" in the title. Perhaps it's all relative but the main reason I didn't start my boy on this was because I just did not have the money (also was unaware of the research and thought it was a crapshoot). It would've cost me well over $600 for a 1 month supply for a big dog his size. Maybe it's inexpensive if you have a chihuahua.


Laura 11 months ago

The dosage is given in milligrams per kilogram of body weight so a 30 kilogram dog would require 3,000 mg per day.


Solaras profile image

Solaras 11 months ago Author

Hi Laura: Thanks for your comment. I checked on Amazon and found a number of alternative makers for the turkey tail mushroom extract that are significantly less expensive than I'm Unity. While the trial was performed using I'm Yunity, you may find very similar results using Swanson at less than $20.00 a month for a 60 pound dog.


Lynn 10 months ago

What is the difference between I'm Yunity and inexpensive Turkey Tail?


Solaras profile image

Solaras 10 months ago Author

The problem with any "supplement" is that they are not regulated by the FDA in the same way many other products are. Investigators have found that some supplement capsules contained nothing more that dust in them.

The Penn State researchers used I'm Yunity, and found that the product was consistent in delivering the amount of mushroom extract that the label promised to deliver. The less expensive version from Swanson receives very high grades 4.5 stars from users with dogs battling hemangiosarcoma tumors as well as humans battling their own precancerous cells and tumors. However, I am not aware of any studies testing the amount or quality of the Swanson brand Turkey tail extract.


Cindy 8 months ago

You are incorrectly stating that this study was done by Penn State when in fact it was done by the University of Pennsylvania. They are two different schools. I know this for sure because my boxer just had her spleen removed by a surgeon at the Univ. of Penn because of hemangiosarcoma and as they are currently doing another clinical trial with I'mYunity we were offered the chance to particiapte. We chose not to as we wouldn't know if our dog would be receiving the I'mYunity or the placebo. We bought I'mYunity on line and yes it is very expensive. We hope it will help extend her life. She is also receiving chemo.


Solaras profile image

Solaras 8 months ago Author

Hi Cindy - Thanks for that correction. I hope that the I'mYunity does help. Please keep us posted on how your boxer is doing, and any insight your vet has to offer on her progress.


Cindy 8 months ago

Thank you. We know that neither the chemo or the I'mYunity will cure her cancer but hopefully it gives us more time with her. I will post updates occasionally if you would like.


Solaras profile image

Solaras 8 months ago Author

Everyone would love to know how she is doing. Please check back with updates on her cancer prognosis.


Steve 8 months ago

Our Max was just diagnosed last week with hemangiosarcoma following surgery to remove the spleen and a tumor which was beginning to spread to the stomach pancreas too. We will not do chemo because he is very sensitive to all medications and he does not need any more suffering. After researching the studies at U PENN, we ordered Turkey- Tail which should be coming any day. Our concern is getting him to take it and holding it down. He is the first mini schnauzer I've read with this disease so far. Any info is helpful


Danielle 8 months ago

has anyone tried or heard of mush? it has turkey tail in but also a bunch of other mushroom blends. Im trying tofigure out which one would b better and also maybe less expensive for my bull mastiff mix who was just diagnose with hemangio sarcoma:( the worst incurable cancer....


Solaras profile image

Solaras 8 months ago Author

Hi Danielle: I am sorry to hear about your bull mastiff. I know how devasting this diagnosis is. I would stick with the Turkey Tail Extract, as that is the only one I know of that has been tested to treat hemangio sarcoma effectively. I have not heard of mush before.


Karen 7 months ago

My dog became very ill suddenly last week; a large mass was found on her liver and it is presumed she has hemangiosarcoma. We are treating her with Yunnan Baiyao, ($9 for a box of 16 capsules) which has clearly stopped the hemorrhage, and Wellmune Immune Health Basics, 500 mg. The cost for the Wellmune is approximately $60 per month. Nobody can believe she almost died 5 days ago, she's running around and wanting to play. Hope it lasts.


Solaras profile image

Solaras 7 months ago Author

Wow Karen: So sorry to hear your girl has cancer. That is an amazing turn around. I hope it does last for a while. In the study, some of the dogs had lasted a year, without any other treatment, and were still doing well when the study ended.

Please keep us posted!


Vicki 7 months ago

My 11 yr old border collie was diagnosed with haemangiosarcoma just a few weeks ago. Our horrible journey all started when she knocked her leg jumping into the car & investigations led us to a very large mass in her thigh which is the primary tumour. It has been very hard to find information on prognosis when the primary is not the 'usual' places. She has metastasis throughout her body so we have opted not to use chemo. Today, our package of I'm-Yunity arrived (3 days delivery from USA to New Zealand! Very impressive) so I am hoping that it at the very least, makes her more comfortable by limiting the growth of the other tumours. What's to lose? It is expensive, but it's cheaper than chemo. And apparently it's very tasty... :)


Solaras profile image

Solaras 7 months ago Author

Hi Vicki: Please keep us post on your girls progress. I hope it helps make her more comfortable.


Renee 7 months ago

Does it work as a preventative? I lost my Aussie last year to this horrible cancer - I wish I had known about turkey tail. I still have another Aussie - whos Mother is my other boys sister. I read this cancer is hereditary :-(. I'm wondering if I give it to my boy as a preventative measure it can't hurt? Any advice would be welcomed. I can't bare to lose another boy to this horrible cancer.


Solaras profile image

Solaras 7 months ago Author

Hi Renee: The researchers saw no bad side effects from the turkey tail mushroom extract. People in China have been taking it for millennium; I can't see that it would hurt, and may very well provide protection. This is a cancer that is difficult to treat because it is usually diagnosed at such a late stage. If you suspect that your dog may be predisposed to it, I would invest in the extract.


Renee 7 months ago

Thank you! That is good advice. Its such a horrible cancer - my first boy who passed from it was "fine" - had just been to the vet for his annual check up - clean bill of health, ran agility that morning, in the evening wouldn't eat his dinner - I thought he ate something "off" - took him to the vet - HUGE tumor on his spleen had burst, lungs loaded with cancer too so surgery was not an option, passed that night. I wish I had known about the Turkey Tail back then - maybe would have had a few additional months with my boy. :-( Thank you! I'll give it to my boy now - like you said can't hurt! :-)


Vicki 7 months ago

My girl lost her battle today. I knew I'm Yunity wasn't a cure for this nasty cancer but I hoped that we may have more time, perhaps we just heard about it too late. What I do know is her last days were more enjoyable than not and her appetite was fantastic right up to the end. So that's us. It's been a very sad day in our little family . :(


Solaras profile image

Solaras 7 months ago Author

Hi Vicki- So sorry you lost your girl to this disease. It often is the case that it is very advanced before we even know there is an issue.. Dogs tolerate it well until the tumor ruptures. They are working on a way to diagnose it early from a simple blood test. That could be a real game changer. I will update with more info on that as the testing progresses. For breeds that are susceptible to hemangiosarcoma, it could become part of the annual physical, and help us catch it before it has metastasized.


Vick 7 months ago

Thank you :( Let's hope the research pans out. In all that I read, border collies were not in the top ten breeds so I would be interest to hear how it pans out for dogs not considered susceptible.


Solaras profile image

Solaras 7 months ago Author

Hi Vicki - Border collies should be up there. I had one die at 4.5 years from cardiac hemangiosarcoma, and I know of 3 more that died at that same age + many more dying around the age of your dogs. It appears to be on the rise in the breed.


Laurie 6 months ago

I boy Nestle who is a 10 year old German Shepherd had emergency spleen surgery two weeks ago. Pathology came back cancer. Ordered the I'm Yunity and hopefully it's here today. Just want more time with my sweet boy.


Cindy 5 months ago

I wanted to let you know that our Maggie crossed over the rainbow bridge on May 23rd, a little over 3 months after having her spleen removed, 5 chemo treatments given every 2 weeks and the little bit of I'mYumity we were able to get in her as the chemo was very hard on her - no appetite, throwing up. We had really hoped the chemo treatments were going to give us more time with her but it was not to be. In hind sight we wish we wouldn't have put her through the chemo but I guess some dogs tolerate it pretty well and it does extend their lives a bit so we hoped and prayed that it would help her. We have a lot of I'mYunity we would be willing to donate if somebody would like to have it. Please let me know.


Solaras profile image

Solaras 5 months ago Author

Hi Laurie: I hope the turkey tail extract helps! Please keep us posted on your GSD's progress. Best wishes!


Lindsay Hart 5 months ago

Cindy: My 14 year old pit was just diagnosed last night and i'm scrambling to figure out the best holistic treatment asap. I would be happy to take these off your hands, even pay for them. please let me know!


Nicole 5 months ago

My boy who is a daschound of 7 years underwent an emergency splenectomy 1 week ago. Now, just yesterday, the pathology came back and it is in fact hemangiosarcoma. We are considering chemo to extend his lovely life but can he take this supplement as well?


Solaras profile image

Solaras 4 months ago Author

Yes, this supplement has been taken along with chemo and no adverse side effects were noted.


Susan 4 months ago

My border collie was diagnosed with splenic hemangiosarcoma a month ago. Tumor hadn't burst was found while doing a follow up ultra sound for a cancer that was in remission on her liver. Sounds like the dogs life is pretty normal till the end. That's what scares me the most is not knowing what the near future holds. Her spleen was removed and I had immediately ordered the I'm yunnity and the Yunnan baiyou which she has been on trying to stay positive and love on my girl as much as I can just don't want her to suffer in any way. She deserves so much more than that. Still hurts more than anything I've felt for a long time. Just want to do best by her


Jennifer 3 months ago

Hi there,

My pup Daisy a Staffordshire Terrior Mix was diagnosed with Hemangiocarcoma February 1st 2016, I paid the 5000$ to have surgery to remove it was beginnings of stage 2. We have had her on a holsitic powder I order through my vet but you can order directly as well, Natural Solutions Inc out of New York. H8+h60+H83 Splenic Heman, also she is on Canine CAS Options-Extra Strength Immune & Antioxidant Support tabs. These have the Turkey Tail mushroom in them.

https://www.pureformulas.com/canine-cas-options-ex...

I also feed her a whole anticancer dog food diet, low carbs high protein no processed anything or any store bought dog food. She was supposed to only live for two month and is going on 7 months right now acting like a puppy. I highly recommend these things for a dog with this type of cancer. There is hope!


dawn 2 months ago

My Staffordshire will be 13 next month and is diagnosed with cancer, this afternoon they called me with the results, but are telling me I have to go to an oncologist to know what kind it is. They did say it was not all in one place. He is going to leave me all alone.


Carol 2 months ago

My 8.5 year old Golden (Cutter) was diagnosed with hemangiosarcoma on July 30th. He was absolutely fine that Saturday morning until the tumor on his spleen ruptured - which was removed later that day.

Currently treating him with chemo every 3rd week and supplementing with I'm-Yunnity and Yunnan baiyou. Also feeding him a high-protein no-carb diet of liver, organic chicken, carrots, red bell peppers, salmon, and dark greens (which I cook almost daily). I'm doing everything I can but I know my days with this beautiful creature are few in number - so heartbreaking. Cutter is my 5th Golden over my lifetime and this is the first time I've had to educate myself about this evil disease. I now understand I should consider myself lucky since the cancer is so prevalent in Goldens.

One question - Cutter weighs about 75 pounds and I'm not sure how many I'm-Yunnity supplements I should give him daily. I currently give him 4 in the morning and 4 again in the evening.

My heart goes out to everyone posting here.


Maral 8 weeks ago

My 11-12 yr old lab just got diagnosed with hemagiosarcoma. His tumor is just above the shoulder but wasn't able to be removed. I started him on a raw diet along with fish oil, Hunan baiyo, Xiao Chai Hu Tang, CAS options immunity support, adrenal support supplement and milk thistle. The holistic vet I met with also recommended ozone blood transfer therapy weekly for 8 weeks. I wanted to see if anyone tried this and your experience. Our regular vet said this cancer is aggressive and no way of knowing if it spreads. I just don't know if it's worth doing the ozone therapy and there's very little info about it online in canine use.


Solaras profile image

Solaras 8 weeks ago Author

I have heard of the ozone therapy being given rectally, and that the owners believed it was very helpful for their dogs overall condition. The blood transfer sounds very expensive and risky.

The yunnan baiyao is supposed to stop the internal bleeding from the ruptures in the hemangiosarcoma tumors.


Krsiten 7 weeks ago

First of all if you are reading this I am so so sorry about your friend being diagnosed with this horrible disease.

Back in June 2016 we noticed our dog (husky/shepherd mix) was not eating so we took him to the vet who noticed a mass in his spleen. Within 3 days he had a splenectomy and was diagnosed with hemangiosarcoma. The internist gave us 2 months. I was speechless.

As soon as he got out of the hospital he was like a new dog- energetic, playful, etc. I thought to myself "there is NO way this dog is dying in 2 months!" We immediately started him on ImYunity (every day) Yunnan Baiyo (every other week) and Cannapet treats. One week later we started doxorubicin (chemo), which required intravenous administration every 3 weeks. For all of July and August the dog was fantastic while taking all of these treatments- eating like a champ and acting like a puppy. No side effects from chemo, etc.

Then one day in mid Sept all of a sudden it turned - one morning he didn't want to get up, didn't want to play and didn't want to eat. The vet had always told us "he will be great until the day he's not" , and I realized that that day had come. We had to put him down 2 days later. It was 10 weeks after his surgery. It happened too fast.

I do think that the supplements helped make him feel better and I am glad that we tried our best and gave it our best shot with every treatment we could. The reality is that no matter what you do there is no stopping this beast, although we truly convinced ourselves we could. My advice to anyone going through the same situation is to think each decision through. We were lucky enough to have the financial means and time at home to take care of our dog, and I am grateful for that. In the end it is heartbreaking no matter what.

I am looking to donate our supply of ImYunity to anyone who needs it. I bought a 500 pill supply ($595) and there are about 300 or so left. If anyone is interested you can email me at krissy_m21@hotmail.com and please make sure you write ImYunity in the subject. I get a ton of mail on that account.

Best of luck to everyone!

Kristen


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Solaras 6 weeks ago Author

Thanks so much Kristen for visiting, sharing your story and your generous offer!

I am sorry you only got 10 weeks after diagnosis with your furry friend. Results definitely vary with each dog. For many it is one day from diagnosis, which gives owners no time to prepare.


Karen Hall 4 weeks ago

TY Krsiten... We include Yunnan Bayou in Bart's supplemental regime. He was diagnosed 10 months ago (we were prepared for him going into back surgery). He's had a splenectomy, 5 big doses of chemo, another surgery to remove a lesion on his liver (and part of his liver) and recently a small mass on his omentum.


Solaras profile image

Solaras 4 weeks ago Author

Hi Karen: That is wonderful that you have gotten 10 months with Bart. What is you full supplement regimen? Are you working with a holistic vet?


Bobby 6 days ago

To the people above my write up..l am so sorry to hear this devastating news, an l can relate how this cripples our whole world. My 4.5 yr Pitty that l rescued just 18 months ago was diagnosed 4 weeks ago with Terminal Osteosarcoma, in her right wrist above her foot. My vet gave her less than 7weeks,

l was consumed with grief as she is like my human kid..where most of you can agree completely. I stopped mourning an started fighting for my baby, l changed her eating habits in 3 days got her on the Budwig Protocol, 3x a day, Bison Marrow bone broth 3x a day, and organic food and lightly cooked beef bison, with turmeric and organic Flax seed oil, and l got her on Cannabis oil with a 1:1 ratio of THC an CBD! Oh yes l did, dogs and people have been literally cured!..to all who are reading this ..check out Utube, research dogs an cannibis oil!..l just had her brought into my vet to get her splint rebandaged, the vet was shocked..No Swelling, No Pain apon manipulation..you can get your vet to give you a referral an a prescription for a Dispensary..I would never see her on the chopping block an then chemo, l seen my father die from that..my vet is doing headshakes at her continued healing she is transitioning through...l will be getting another X-ray on her 8th week ...an l can't wait to see the results. Mother Nature has a cure for everything, and she is proving it right before my eyes. it's an edible oil that l administer to her with either organic coconut butter or honey.. Don't Give Up, have faith in the Universe!...

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    Barbara Fitzgerald is an AKC Breeder of Merit and the author of a column, Conversations with Champions, for the BCSA magazine, Borderlines.



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