Canine Degenerative Myelopathy and My Experience

Updated on December 13, 2018
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Our Wirehaird Pointing Griffon was diagnosed with Degenerative Myelopathy at the age of 8 years old. This is how we coped with this disease.

Wirehaired Pointing Griffon - Griffon Korthals
Wirehaired Pointing Griffon - Griffon Korthals | Source

What Is Degenerative Myelopathy (DM)?

Canine degenerative myelopathy (DM for short) is the incurable, progressive degeneration of a dog's spinal cord which results in a general paresis of the back legs. It is similar in many ways to amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) in humans.

Halfway through November 2003, our dog Tsjip was diagnosed with DM. By April 2004, she had more and more difficulty walking. Long walks had already been out of the question for a long time. She would potter around a bit outside to pee and poop, sniff around, and then go back inside. The disease progressed slowly and painlessly, until eventually her quality of life was compromised and we were faced with one of the most difficult decisions pet owners have to make.

Have You Ever Heard of Degenerative Myelopathy?

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Our wirehaired pointing griffon (Griffon Korthals) Tsjip-February 2003
Our wirehaired pointing griffon (Griffon Korthals) Tsjip-February 2003 | Source

Canine Degenerative Myelopathy Symptoms

DM or ALS starts by losing control of back legs. It's causing weakness and loss/lack of coordination in the muscles. I'll describe what we saw happening to our dog from the start.

One day in November 2003 when Tsjip was 8 years old, we noticed that she was limping a bit on one rear paw. The limping was more like a series of short waggles and was initially hard to notice. At first, we thought she had misstepped, but after a few days, it didn't go away and even got worse.

We decided to see a veterinarian, and after many tests, he ruled out everything other than DM. This was awful news for us because just two weeks prior, we had lost her sister, Sarah, to Addison's disease after six years of intensive care.

Tsjip developed DM when she was 8 years old.
Tsjip developed DM when she was 8 years old. | Source

What Causes Degenerative Myelopathy?

It is still unknown what the etiology of this disease is. Research has shown that a mutation in the SOD1 gene is a risk factor for developing degenerative myelopathy in many dog breeds. It presents similarly to ALS (Lou Gehrig's disease) in humans.

Before diagnosing a dog with DM, all other spinal cord disorders have to be ruled out, such as intervertebral disc disease or spinal cord tumors which present similarly to DM.

Varying opinions about degenerative myelopathy exist. Dr. Clemmens of the University of Florida likens DM to human MS. Upon the publication of his website in 1998, Dr. Clemmens had expressed an interest and desire to treat the disease like MS, but these plans were not seen through.

Dr. Coates from the University of Missouri, on the other hand, likens DM to ALS, as most scientists do today. The University of Missouri currently runs a DNA test which detects a mutation in the SOD1 gene. SOD1 is thought to be responsible for the enzyme superoxide dismutase, which manufactures the most numerous cell in the canine body. It's possible that DM genetic mutations are also breed-specific. Scientists came to this conclusion after discovering that two carrier dogs and one noncarrier dog still developed the actual disease.

Common Carriers of Degenerative Myelopathy

Degenerative myelopathy is most often seen in the following dog breeds:

  • German shepherd
  • Pembroke Welsh corgi
  • boxer

However, the gene mutation in SOD1 has been found in at least 43 other breeds, including:

  • Wire fox terrier
  • Chesapeake Bay retriever
  • Rhodesian ridgeback
  • Cardigan Welsh corgi

DM Stages

* dog is dragging back leg(s)

* dog's back legs show weakness

* dog is losing control of back legs

* dog's back legs are collapsing

* dog gets paralized

Tsjip and Early Symptoms of Degenerative Myelopathy

Testing for DM Is Possible

Today, it's possible to screen dogs for DM through a DNA saliva test at the Orthopedic Foundation for Animals in Columbia, Missouri. By testing the high-risk breeds, it should be possible to reduce the occurrence of DM. However, interpretation of the results should be done by a veterinarian, so he/she can interpret both lab results and clinical signs for a proper diagnosis. The following table represents the probability of gene mutation carrier status.

Possible Lab Results for DM

Genotype
Status
Results
Normal/Normal (N/N)
Clear
Some cases report that N/N dogs have developed the disease.
Normal/Abnormal (N/A)
Carrier
The dog will not develop DM but can give it to their offspring.
Abnormal/Abnormal (A/A)
At Risk
Likely to develop DM.
A Punnett square will similarly represent the chances of an offspring inheriting the gene mutation from the parents.

DM Dogs: Breeding and Heritability Risks

If you want to know the probability that your pup is a carrier of or at risk of developing DM, this can be calculated using a Punnett square:

  • If both parents are clear, then all of the puppies will be clear.
  • If one parent is a carrier and the other one is clear, then each puppy has a 50% chance of being clear and a 50% chance of being a carrier.
  • If both parents are carriers, then each puppy has a 25% chance of being clear, a 50% chance of being a carrier, and 25% chance of being at risk.
  • If one parent is clear and the other one is at risk, then all puppies will be carriers.
  • If one parent is a carrier and the other one is at risk, then each puppy has a 50% chance of being a carrier and 50% chance of being at risk.
  • If both parents are at risk, then all puppies will be at risk.

How to Treat and Exercise Your DM Dog

Once a dog is diagnosed with DM, it's irreversible and it can't be cured. All you can do is making sure your dog is comfortable. Exercising is good, but don't overdo it. Your dog will tell you when enough is enough.

We kept Tsjip going for as long as we could. She slept on a blanket because climbing in or onto something was difficult for her. This way, she had full sight of us and we had full sight of her. Her bed was also close to the outside door.

Tsjip on her plaid in the living room.
Tsjip on her plaid in the living room. | Source

Today, you can get physical therapy or water therapy for dogs which can help potentially stall the disease process. In Tsjip's lifetime, these options were not available, at least not where I live. While doing my research for this article, I found the following on Wikipedia:

Use of a belly sling or hand-held harness allows the handler the ability to support the dog's hind legs for exercising or going up and down stairs. A 2-wheel dog cart or "dog wheelchair" can allow the dog to remain active and maintain its quality of life once signs of weakness or paralysis of the hind limbs is detected.

We used a belly sling to support her at the end. At that time, I had never seen or heard about the possibility of a 2-wheel dog cart, but I think that even if I had known, I would've chosen not to take it that far.

Tsjip and Late Progression of DM Part 1

Wheelchair Or Euthanasia

The reason why I am not in favor to use a dog wheelchair is that I want a dog to be a dog and be able to do all the things that dogs are supposed to do. The thought of a dog wheelchair looks like the invention of the year. It's helping the dog to get around again. However I wonder; is it really giving the dog a better quality of life or is it giving the owner some peace of mind?

It might be fun for walking outside, but how is a dog in a wheelchair supposed to pee and poop in the way a dog normally does? The moment the dog is back inside the house the wheelchair has to come off or the dog would not be able to lie down and then all temporary mobility will be gone again.

So if you decide to put your dog in a wheelchair: are you doing it for the dog's sake or are you doing it for your own sake. Just think about that.

Would You Use a 2-Wheel Dog Car in Case of DM?

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Tsjip Stayed Playful Until the End

Tsjip was playful until the end and loved to tear our plastic bags apart (she was careful not to swallow the pieces), as you can see in this last video. This video was recorded towards the end when she had a hard time standing up.

She was not in pain through the whole ordeal, and we made the decision to put her down at the moment she either became incontinent or couldn't reach her water bowl by herself anymore. The latter came first, and so we decided to put her down.

Tsjip Playing and Late Progression of DM Part 2

We Lost Both Dogs Within 6 Months

Seeing these videos again makes me feel sad and a bit guilty, too. I always wondered if we waited too long, but you know, she wasn't in any pain at all and you can see that she was still very playful.

It's hard to lose both of your dogs within 6 months' time at a young age. We lost both to two totally different diseases, and both were irreversible and incurable.
Degenerative myelopathy is painless, for all we know, but it's heartbreaking to see this disease progress so fast.

Dogs with Addison's disease can still live a happy life, but will die at some point either from the disease or the heavy medical regimen they have to follow.

Our Wirehaired pointing griffons (Griffon Korthals) Tsjip and Sarah
Our Wirehaired pointing griffons (Griffon Korthals) Tsjip and Sarah | Source

Keep a Close Eye on Your Dog

Be cautious and aware if your dog is not walking the way he/she should. If the change in gate or mobility impairment of the hind leg(s) doesn't go away, your dog could be affected by degenerative myelopathy.

March 2018 Update: Gene Therapy for Canine Degenerative Myelopathy

The other day I got an email from an USA dog owner, telling me that her 10 year old corgi recently had been diagosed with MD. The reason she send me this email was the following and I quote: "they would like to do a Gene Therapy study on my dog to possibly slow down the progression and ultimately it would help humans with ALS" and she wanted to know if I had heard about this study.

I had not heard about it so I searched the internet and found a lot about gene therapy, what it is and how it works. However I also found something interesting on the website of the AKC Canine Health Foundation about Gene Therapy for Canine Degenerative Myelopathy. Let's hope they will get some good results in due time.

Update July 2018: Message from a Dog Owner

The other day a mand called John contacted me through HP and he wrote:

"Thanks for the article. July 3rd i lost my 14 year old lab to what I believe was DM. It wasn't diagnosed, there wasn't time to diagnose it from the moment I noticed back leg problems to the complete inability to use them. Maybe 2 weeks at best. I've done research and initially thought it was hip displaysia, but after I came across this disease and watching videos such as yours and comparing my dog, it was spot on. I agree with you about the wheelchair idea. In fact, today I saw a man with his 2 dogs and one was with wheel chair. I had a brief moment of guilt bcause I could have extended my girls life with the wheelchair. However I came to my senses and realized it would only be good for walks, which is a very small portion of her life. It hurts but she was 14 and to the very last day she still wanted to eat. She loved to eat. For that I am grateful and she lived til 14. My first dog ever and she will remain in my heart til I die. Thanks for sharing your experience. I will keep an eye out on my second dog that I have".

I asked him permission to add his story to my article because I thought it could be important for other people to read that DM can progress very quickly as John just experienced with his old dog. So stay alert when your dog isn't moving the rear legs like a dog should.

Update September 2018: Message from a Dog Owner

Today a woman called Tracy contacted me through HP
:
Hello. I want to thank you for this article. I believe this is what my 13 year old lab had although not diagnosed. We made the very difficult decision to put him down yesterday after being incontinent and immobile for 2 days. My husband had used the belly sling for about 3 weeks. We had bought a wheelchair, but he just collapsed in it so it was not usable. This article makes me feel better that we did the right thing. I was feeling very guilty that we could've done more. So thank you again!

Update December 2018: Message from a Dog Owner

Today a woman called Tina contacted me through HP

Yesterday we lost our 11 yr old Wire Haired Pointing Griffon to DM. Your Tsjip reminded me of him so much. Your story and videos have given me such comfort in deciding to let our sweet boy go. My husband and I would have spent every dime we have on helping him, to keep him with us. But this disease is a thief. It robs our friends of every dignity and progresses so darn quickly, especially in latter stages. Our hearts are broken...our home is empty without him.

This article is accurate and true to the best of the author’s knowledge. It is not meant to substitute for diagnosis, prognosis, treatment, prescription, or formal and individualized advice from a veterinary medical professional. Animals exhibiting signs and symptoms of distress should be seen by a veterinarian immediately.

Questions & Answers

    © 2017 Titia Geertman

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      • Titia profile imageAUTHOR

        Titia Geertman 

        8 weeks ago from Waterlandkerkje - The Netherlands

        #Debie: Sorry to hear about you dog and yes, it's a tough decission you have to make, but you are the only one who can make it. About the cbd oil I wouldn't know. I'm not a doctor nor a vet but if it helps at all, I doubt it will help in the stage your dog is in now. Has you dog officially been diagnosed for MD? In that case your vet should know and can give you advice about cbd oil. Don't let your decission depends on what and how you feel but think carefully about what kind of life lays ahead for your dog. Only then you will make the right decission.

      • profile image

        DEBIE 

        8 weeks ago

        Thank you for this article.. i jave a Belgian Malinois going through this now.. he showed signs three years ago slightly dragging one leg a tiny bit. Hearing the nails scrape. One day two years ago.. he couldn't stand. I'm at the cross roads now.. wait or put him down. His spirit is still 100%.. but his body is rapidly declining now. So heart breaking... i hear cbd oil has worked well but i dont know at what stage... hes pretty advanced so im skeptical if it will work. . . Such a beautiful soul.. i cant bear the thought of playing this hand... doesnt seem fair...

      • Titia profile imageAUTHOR

        Titia Geertman 

        3 months ago from Waterlandkerkje - The Netherlands

        @Robing Flemish: I'm so sorry to learn about the condition of your old lab. know it's a tough decission you have to make, but reading your story I know you'll make the right one on the right time.

      • profile image

        Robin Flamish 

        3 months ago

        Hello all, so glad to have come across this information..I too have a chocolate lab soon to be 12 years of age ...of course need I say the love of my life. Last year i noticed my girl having problems breathing..heavy panting..difficulties dealing with the humidity and heat, we of course made an appointment and discovered she was dealing with the flaps in her throat were not allowing air to get in to her lungs, so we opted to have surgery to tie back one side to relieve the problem and give her a new lease in life. One year later all was much better until a month ago when she began to loose the ability to jump on my bed..stand up..go for walks etc. I cant begin to express how painfully emotional all of this is to see..absolutely crushing! I have since learnd that whatever causes the flaps in the throat to collapse is as well connected to the nerves in her back and hind legs which has resulted in this degenerative condition you speak of through these threads.Needless to say, when she can no longer walk or needs to be lifted up...it will be time to lay her down. My heart is heavy...keeping her alive with no quality of life would only prove to be selfish and with no regard to her. Love your pets, take good care of them with all your heart! They depend on us to give them a good life.

      • Titia profile imageAUTHOR

        Titia Geertman 

        3 months ago from Waterlandkerkje - The Netherlands

        #Rininta Sen, so sorry to hear about your dad. Yes it can happen to dogs too, but quite often the vets don't recognize it.

      • Senoritaa profile image

        Rinita Sen 

        3 months ago

        I lost my dad to ALS. I didn't know it could happen to dogs as well. I still keep reading up on what is new with ALS research, and I need to look up the gene therapy. Your dog was beautiful, and I am glad she went without much suffering. Thank you for your article.

      • Titia profile imageAUTHOR

        Titia Geertman 

        4 months ago from Waterlandkerkje - The Netherlands

        As I stated in my article, Lou Gehrig's desease (ALS) in humans and DM in dogs have very similar symptoms.

      • profile image

        Theresa Christensen 

        8 months ago

        Lou Gehrig's disease

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