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Itchy Dog? Prednisone Alternatives To Avoid the Serious Side Effects

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Dr. Mark is a veterinarian. He has been working with dogs for more than 40 years.

Natural prednisone alternatives are available to help your dog avoid the serious side effects.

Natural prednisone alternatives are available to help your dog avoid the serious side effects.

Alternatives to Prednisone for Itching Dogs

Since steroids first hit the market in 1949, many vets have used them as the best alternative treatment for dogs with itchy skin. They have become so popular that some clients expect to come into the vet clinic and get “that allergy shot."

Why do we use them so much? Well, one reason is that they do work. Prednisone and other steroids are quick solutions and often provide almost immediate relief. They are not a cure, however, and there are many problems and side effects associated with them. You may be wondering:

  • What are the problems that can hurt your dog when prednisone is used?
  • Are there alternatives so that you can avoid those side effects?

The Side Effects of Prednisone

  • Many dogs drink more on prednisone. Since prednisone affects your dog's ability to control the water level in his body, he will drink more, and then he will have to urinate more. When a previously house-trained dog has to go in the middle of the night and no one will let her out, accidents do happen.
  • Dogs are hungrier. Prednisone stimulates the appetite and dogs will want to eat all of the time. They do not burn up more calories, however, so weight gain is a problem.
  • Your dog might mope around. One side effect you might notice is that your dog does not want to get up and go for a walk. His back legs might be weak from muscle wastage, or he just may be lacking in energy.
  • Some dogs pant a lot. This is a common complaint for those people that allow their dogs to sleep in their bed.
  • A dog's skin problem can actually grow worse. Dogs might be treated for an itching problem and then start losing hair, develop blackheads, thin skin, or even a large area of hairless and scaly skin known as “calcinosis cutis."

More Side Effects

The dog in the video above has a disease that mimics the side effects of long-term prednisone dosing in the dog.

Other side effects include:

  • Your dog may develop new infections. Since prednisone depresses the immune system, some dogs will come up with an infection in the bladder or the gums.
  • Dogs vomit and may have other GI upsets. This is not as common as the increased thirst and hunger, but when it happens it can be serious.
  • Dogs may also have behavioral problems or uncommon reactions that are not included in this list. If your dog is sick and a steroid injection is suggested before other things have been tried, think about the side effects.
  • Some dogs have even more problems with prednisone: muscle wasting, changes to the muscle of the heart, pancreatitis, and even blood clots and stroke can occur in some cases.
All dogs with itchy skin should have their diets changed to natural food.

All dogs with itchy skin should have their diets changed to natural food.

Alternatives to Prednisone

Steroids like prednisone are dispensed for many different problems and at times are the only medication available that will help a dog. If your dog is being treated for a skin problem, though, there are a lot of other things you can do that might help.

  • Improve your dog's diet: Just switching brands is not enough to help your dog avoid steroids and deal with his skin problems. Learn how to feed your dog healthy raw food that contains the essential vitamins, enzymes, essential fatty acids, and other nutrients he needs to improve the quality of his skin.
  • Shampoo: Some skin diseases will respond to frequent shampooing to remove the allergens that cause excessive itching. All dogs will respond to the cool water and cleaner skin. No matter which product you use, most of them help.
  • Flea control: The most common cause of scratching in dogs is still fleas. Some dogs are so allergic to the saliva of the flea that only one bite will make them chew their skin. Even if no signs of fleas are present, over half the dogs that are presented with skin problems are afflicted with fleas, so all dogs should be protected against fleas before starting a prednisone trial or even one of the alternatives.
  • Natural alternatives: Some herbs and other natural substances can reduce inflammation of the skin, relieve itching, and make your dog comfortable enough to avoid prednisone. Most of them have few side effects and can even help your dog in several ways.
  • Antihistamines: If your dog's allergies are not that severe, sometimes just an antihistamine will take care of his problem. The antihistamine may not be as fast, and it may not clear things up 100%, but your dog's health is a lot less compromised.
  • Prescription allergy suppressants: Some of the drugs that have been developed for use in dogs with allergies may end up being as bad or worse than steroids. Natural alternatives should be tried first, but even if they fail there are new medications that can be tried.

Improving Your Dog's Diet

When presented with a dog suffering from itchy skin, the first thing I recommend is a radical diet change. If you want to try alternatives instead of prednisone, this is a great place to start.

I am not talking about buying a different brand of dog food. The processed dog foods sitting on the shelf of your grocery store may each be different, but one thing is the same: They are all processed and have been sterilized enough to be sitting out on a shelf.

So what does a dog with skin disease need? There are suggestions, but we probably do not know. We know a lot more about skin problems than we did 100 years ago, but does that mean we know everything a dog needs? Foods that announce that they are 100% complete are formulated based on research that was done years previously, and it may be inaccurate. A natural diet made up of the raw components described below provides more than that.

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Read More From Pethelpful

Does a diet change always prevent a dog from needing prednisone?

No, your dog food can have every known essential nutrient required, and in excess, and if he is allergic to some things, he will still have symptoms on an improved diet. So why even bother trying?

We try an improved diet because it will help some dogs. Dogs that have been fed cheap food, or even good food that is marginally deficient or deficient in ways that we do not even know about, may improve dramatically.

No, we do not know everything yet. What we do know is that your dog's diet should be made up of:

  • About 50% raw meaty bones: Grass-fed beef, chicken carcasses, tails, etc.
  • About 25% soft meat: Beef cheeks, beef hearts, beef tongues, and other cuts of meat available cheap from your butcher.
  • 10% organ meat: To provide the other vitamins and minerals your dog needs, add some kidneys, liver, lungs, and other internal organs.
  • 10% vegetables: As long as you are willing to blend your dog's veggies so that he is able to digest the cellulose, you can supplement with broccoli, green leafy vegetables like spinach, and carrots.
  • About 5% eggs, fruits, and fresh fish: As an added source of calcium, you can give the eggs with the shells, add some fresh fruit like papaya or avocado, and once a week or so give a fresh fish like mackerel or sardines to supplement his omega 3 fatty acids.

These amounts are not exact. You do not need to get out a scale and figure that your dog needs 1 kilo of meaty bones, 100 grams of vegetables, etc. Just make sure that you are feeding your dog a varied diet.

Supplements are not usually necessary for a healthy dog since this diet will provide what a dog needs. With a dog suffering from allergies serious enough to warrant prednisone therapy, however, it is a good idea to give some of the anti-inflammatory natural therapies that I have described elsewhere. (Licorice, coconut oil, sulfur, and omega fatty acids.)

When you are ready to switch your dog's diet, do some research before switching. There are many good sources out there, and the more you learn the better for your dog.

Bathing your dog can be a lot of work but is one of the best things you can do for itching.

Bathing your dog can be a lot of work but is one of the best things you can do for itching.

Bathing Your Dog

Is there one kind of shampoo that is always going to help a dog suffering from itchy skin? Unfortunately, there is not. If the itching is caused by dry skin, oatmeal shampoo is most effective. If your dog smells like yeast and has thickened and greasy skin, a benzoyl peroxide shampoo is best. If your dog has a secondary infection, then a shampoo with chlorhexidine will help.

If you are not sure of the source of the allergy, the most important thing is to bathe the dog regularly and remove any potentially irritating substances. I cannot give you a definite interval. Some dogs will develop dry skin if they are bathed too often, some will get greasy and start itching if you do not bathe them often enough. I usually recommend about once a week to start and then increase or decrease the frequency based on how he or she responds.

Try a good cleansing shampoo (labeled for dogs, like benzoyl peroxide) and use it about every week to start. If it works, stick with the same product. If it does not, try another shampoo.

Natural Alternatives

Many natural alternatives are available. None of them are going to work as fast as prednisone, so be prepared to watch for any changes for several weeks:

  • Licorice: This is the alternative that I encourage all clients to try before steroids. It has a glycoside (glycyrrhizin) that works similar to steroids, although not as effectively, but does not have many of the side effects. (If you do try and use this plant, be sure to buy the product that makes licorice tea. You can make about one-half cup with a teaspoon of licorice root powder each morning and then give your dog about 1.5 ml for every 10 pounds of body weight. Some holistic vets do not recommend giving it more than a few weeks because of the potential for potassium loss, but since many allergic dogs will need help for longer than this during the allergy season, it is okay to give it longer. Just make sure you supplement your dog's daily potassium intake, like giving her a banana every day.)
  • Coconut Oil: This natural product improves your dog's skin and may be all that he needs. Coconut oil has some natural antibiotic effects and may reduce a mild skin infection secondary to allergies. It also has a high level of antioxidants that will moisturize your dog's skin, and since the itching may just be to dry patches that you are not able to notice, coconut oil will provide relief.
  • Sulfur: This product is normally just sold as a solution for killing mites, but I recommend it for many dogs with skin diseases of unknown origin. For best results mix the sulfur powder with virgin coconut oil (about 1 part sulfur to 2 parts coconut oil) and apply it to any inflamed areas of the skin. If the dog is allergic to mites or is itching secondary to a mild bacterial infection, the sulfur will help. (When using this product, I think it is a good idea to apply it outside and make sure it is all absorbed or removed before coming back inside. If you do not and your house has carpets, he will roll around and stain them.)
  • Fish Oil: This supplement takes some time to work but makes the skin less likely to produce the components of inflammation and itching. Cold water fish oil is best since it contains a high level of omega-3 fatty acids. I am not talking tiny amounts, like those available in dog foods labeled “extra omega acids added.” Your dog needs at least 70mg/kg per day of omega 3 fatty acids, and if he is getting a source of omega-6 acids (like coconut oil) he will need even more. The best way to provide it to him is by giving fish oil in the form of fresh mackerel or sardines, but if you do not have a good source then fish oil capsules can also be given.
  • Yucca: Some holistic vets have tried this herb and found that it is helpful as a prednisone alternative, but there are side effects. It can upset the GI tract of some dogs, and since it has not been used a lot, it may affect many dogs.

Antihistamines and Prescription Alternatives

The next step to help your dog is not as mild as a diet change or a shampoo. To provide quick relief, however, it is sometimes better to give him an antihistamine. Benadryl (diphenhydramine) is not approved, but it is an antihistamine that has been used for many years and is safe when used in controlled doses by a veterinarian. An itching dog can be given about 1 mg per pound, so you can ask your vet about this option. (The pills are small and easy to hide in a piece of cheese or another favorite treat.) Benadryl tends to make dogs a little sleepy, but that is a good thing since he will not be scratching when taking a nap.

Unfortunately, diphenhydramine is only effective when it happens to work. Antihistamines work in a lot less than a third of the cases, so some vets that use them instead of natural substitutes for prednisone will have a series of drugs to try and find out which one might be effective.

If the antihistamine is not enough, you will need to talk to your vet about some of the other potent new drugs available for itching. Some dogs will do better with a cyclosporine pill (Atopica), but it is a potent immunosuppressant and does cause upset stomachs and other problems in some dogs. Others do well on a drug called Apoquel but it too can have a lot of side effects and should be avoided if possible.

The Best Thing for Your Dog

If your dog is scratching, it is a sign that he is in great discomfort. Some people will search for help at the first sign of problems, while others will wait until their dog is chewing all night and has irritated his skin.

Do not wait. Dogs are stoic animals and will not let us know about many of their problems until they are already serious. If your dog has started to chew on his skin, he is already in great discomfort. Learn everything you can about skin diseases in dogs, and get him into your local vet for an exam as soon as possible.


This article is accurate and true to the best of the author’s knowledge. It is not meant to substitute for diagnosis, prognosis, treatment, prescription, or formal and individualized advice from a veterinary medical professional. Animals exhibiting signs and symptoms of distress should be seen by a veterinarian immediately.

Questions & Answers

Question: Can I give my big dog prednisone for hair mites?

Answer: No. Corticosteroids like prednisone cause immune suppression. If you give a dog with mites prednisone he will get worse.

© 2018 Dr Mark

Has your dog had problems taking prednisone? If so, please leave a comment.

Dr Mark (author) from The Atlantic Rain Forest, Brazil on June 30, 2020:

Corinne, there is always an alternative.

Your dog will almost certianly be okay after one therapy with this medication but you do not want to make it a habit. If your vet is not willing to look for alternatives you need to think about finding someone else.

The aurizon is another steriod.

The ear cleaner has aspirin, a non-steroidal anti-inflammatory. You may want to look into this option if the ears are not scratched up

Corinne jane bailey on June 30, 2020:

Hi, I am really concerned

I took my rescue staffie to a new vet because she had terrible ears , scratching , not much and or occasional shaking of head

The vet prescribed virbac epiotic, and aurizon but also prednicare steroid, I am really scared of using this and the vet said there isn't an alternative

My previous rescued staffie passed away at 10 years with many complications including cushions disease, we had used steroids on her when she was younger and I blame the steroids for illness, and maybe she could have lived longer than 10, I have read this steroid or any can causes all sorts of health issues ,please can anyone advise , it just seems to be her ears and they don't seem to be bothering her too much

Desperate for help, too scared to use the steroid but happy to use the ear cleaner and aurizon


Gerald Nobles on December 03, 2019:

He's gaining weight and it is not a good thing to do over a long time. He's older pit. He hacks when out. It's just a relief I know.

Dr Mark (author) from The Atlantic Rain Forest, Brazil on March 25, 2019:

Mandy, if you are giving whole cooked vegetables they are passing through without doing any good for your Basset. They have to be finely blended to be digested by a dog.

You can cook the meat but will still need to worry about calcium and other vitamins that are destroyed by cooking. If you cook it the offal is worthless. Cooked bones will not help your dog either.

Mandy on March 24, 2019:

I am very certain that a change in diet is the way to go for our very itchy Basset. BUT I am really not sure that I can cope with the raw food option. Is it still beneficial if you cook the veg and meat? I am trying a 50/50 mix of meat (chicken offal and soft meat) and vegetables, but have no idea if I am on the right track

sprickita from Reno on February 17, 2019:

Some years back I had the pleasure of boarding with a roommate whom adopted a pitbull pup.

Sweet little girl ( the pup) indeed, though the poor thing had such problems with here skin. She clearly ichy, irritated & uncomfortable constantly ( when she thought she was being sneaky nawing away at which ever part of her was giving her static at that moment) she left huge bleach spots or whitened out at leaat - large circles of ??? Clean??? Like verywhere she parked herself (comfortably).so...

The owner took her to his local veterinarian and had a 400 algery panel done. The vet recommended different foods , bottled water as opposed to tap etc . Long as story short- thank you this artical has been most helpful, & I will 4 sure pass it on.

Ridgeback story on November 25, 2018:

Hi all, i wanted to share our experience with a vet who prescribed P to my girl, for allergy relieffor longterm at a low dose. Gabby was receiving 5mg every 48 hours for quite some time upon the diagnosis and advice of our vet. I am embarrased to admit that i took his assessment as face value and trusted his expertise without question. Had i undertaken some research in the matter, i would have learned this is not the ideal roite to take, as it is UNSAFE and possibly DANGEROUS. Take it from me, It simply is not worth it. After an acute kidney failure accompanied by a lengthy stint in the emergency hospital, an e coli infection and a mean case of calcinosis cutis, not to mention sleepless nights all within 1 month, I am now a voice of caution to anyone considering the viability of P for their family pets. I have also abandoned the previous vet for an holistic vet for all of her future care. Thanks for reading this, i wish you all the best.

RTalloni on November 12, 2018:

One side effect of steriods often dismissed by docs is damaged eye-sight. Thanks for alternatives for dogs.

Liz Westwood from UK on November 12, 2018:

This is a very useful article. It sounds like steroids for dogs can bring as many side effects as they do with humans.

Miebakagh Fiberesima from Port Harcourt, Rivers State, NIGERIA. on November 12, 2018:

Hi, Dr. Mark, thanks for weighing in and commenting. Good day.

Dr Mark (author) from The Atlantic Rain Forest, Brazil on November 12, 2018:

Hi Miebakagh we do not have that Blue Buffalo brand here so I am not sure it is available where you live either. A lot of other good choices though, and of course the best choice is natural, the way it has always been.

Can you imagine paying 8 billion US$ for a dog food company. They are going to make that profit back, so you know they are going to use as cheap a filler as they can find.

Miebakagh Fiberesima from Port Harcourt, Rivers State, NIGERIA. on November 12, 2018:

Good to note.

Bob Bamberg on November 11, 2018:

Hi, Doc, I'm continuing treatment. Sept. scans weren't what we hoped for but it could be worse. I'm starting to get some side effects now that are mildly bothersome, but I'm going through life pretty much normally. Will see my oncologist this Thursday, so will know more then.

You're right about Blue Buffalo. They had some recalls last year, lost their Whole Dog Journal recommendation last year, and this year got sold to General Mills. Many of the stores that I service report diminishing BB sales, plus some are phasing it out in deference to other high end foods.

Ellison might be interested to know that they also use alfalfa meal (hay) and barley grass as part of their fiber package. A dog with a grass allergy or intolerance may find that problematic. Everyone's watching them so we probably won't see an ingredient compromise, but look for the bags to shrink in size and the price to go up. General Mills paid 8 Billion (with a B) for the company and they have to recover that investment.

Dr Mark (author) from The Atlantic Rain Forest, Brazil on November 11, 2018:

Ellison, be sure to check my profile as there is an article about dry skin that may be helpful.

Blue Buffalo used to have a lot better reputation but I have heard some discouraging things about it lately. My personal preference would be to change, but I realize not everyone is willing or able to make up a diet at home.

Thanks for reading. I hope all goes well with the new canine member of the family!

Dr Mark (author) from The Atlantic Rain Forest, Brazil on November 11, 2018:

Heidi, I wish you all the best of luck with that. It does show promise and so far none of the prednisone side effects have been seen.

I used to see a lot of atopy when I lived in the Chicago suburbs, even more than down here where I live now.

Dr Mark (author) from The Atlantic Rain Forest, Brazil on November 11, 2018:

Bob, it is the same everywhere. The dog has a problem, I suggest a potential solution, but then the problem comes up--it is too much work. Oh well. (I even had a question on one of my raw food articles this week "What is the best dry dog food?" You can be sure I deleted it.

I hope all is going well up there with you. No news is good news?

Bob Bamberg on November 11, 2018:

Interesting article, Doc. I know better than to defend high end commercial dog food here, however I do find it interesting that, while you don't trust the U.S. Government's regulation of dog food, you do site the National Center for Biotechnology Information, which is part of the National Library of Medicine which, in turn, is part of the National Institutes of Health. Are we mellowing?

Very few pet owners around here would take the time to follow a regimen such as you describe, and most vets and professional organization (American Veterinary Medical Ass'n, American Animal Hospital Ass'n, American College of Veterinary Nutrition, etc.) discourage raw diets. I know you take a dim view of them, also.

But for those who would devote the necessary time to formulating the diet you suggest, this is an excellent resource, as your articles always are.

Heidi Thorne from Chicago Area on November 11, 2018:

Our one dog has skin allergies that flare up seasonally (usually spring and fall). We're trying Cytopoint shots to avoid the steroids. We'll see how that goes. But glad to find some more alternatives to try. Thanks!

Ellison Hartley from Maryland, USA on November 11, 2018:

I just adopted a new little mutt dog, she is perfect besides seeming very itchy, I definitely will try some of your suggestions. Her skin is dry and itchy so I think that maybe coconut oil would be a good start. The food she came with is blue buffalo moist food I need to look into that as well, not sure if that is good quality or not.

Miebakagh Fiberesima from Port Harcourt, Rivers State, NIGERIA. on November 11, 2018:

Hello, Dr.Mark, I am not a dog owner. But as an avid reader, I do read for interest and leisure. I have noted the pieces of information that I can pass to friends who have a dog. Thanks for this informative story, and happy Sunday!

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