Zylkene - A Remedy for Stress Relief for Dogs and Cats

Updated on January 27, 2015

What Symptoms Does Zylkene Help?

Zylkene helps animals adjust to change and handle stressful situations. It may also be a solution for stress-related behavioural problems such improper urination, over-grooming, separation anxiety, training, and even shyness in cats.

There are many possible reasons for stress. Animals need stability, and like humans, often get triggered by big changes. Here are a few examples of things that can stress out your dog or cat.

  • A new house
  • A new baby
  • A loud noise (especially ongoing, such as construction)
  • Placing the animal in a strange place for a period of time
  • A trip
  • A new animal in the home

Zylkene does not cause sleepiness, but rather just calms the pet down. It can be administered with other natural products such as rescue remedy and pheromones, as well as with prescription medications.

Zylkene can help your dog or cat adjust to a stressful situation like moving.
Zylkene can help your dog or cat adjust to a stressful situation like moving. | Source

What is Zylkene and How Do I Administer It?

Zylkene is made from a milk protein and is classified as a food supplement. The active ingredient is a peptide that has the ability of impacting brain receptors, resulting in a soothing effect on the animal. It is effective for both cats and dogs. It can be purchased in three different sizes of capsule and the choice is determined based on the size of the pet.

  • Dosage: Zylkene comes in pill form, and there are three different dosage options: 75mg, 225mg, and 450mg. Make sure to check the instructions on the box and make sure you are giving the right dosage to your animal (they will have guidelines depending on your pet's weight).
  • How to Administer: The pills can be opened and the contents sprinkled on food, or the entire capsule can be given orally once a day. Most animals find it palatable, and owners find it easy to administer.
  • How Long Should the Treatment Last? Zylkene is suitable for both a short-term treatment, which could be for a few days, or for longer periods if needed. Usually a course is given from between 2-4 weeks. If you know about a stressful situation in advance, like a move to a new house or a new pet, it's advisable to begin administration at least 8 days before the expected stressor, when possible. The medicine should be given once every day and can be doubled if the situation is exceedingly stressful.
  • When Do I Know It's Working? You almost certainly won't observe an immediate change in your pet. However you'll probably notice some small changes within a few days. Continue using the medication until you feel that the outside stress has abated. If in doubt, ask your veterinarian.

Cats are notoriously bad at dealing with change. Zylkene can help them adjust to new situations.
Cats are notoriously bad at dealing with change. Zylkene can help them adjust to new situations. | Source

Does Zylkene have Side Effects?

Zylkene is a non-prescription drug and is safe, as it is a natural product. Zylkene is not known to have any side effects and it can be given with other treatments. Zylken is even appropriate for sensitive animals, as it is hypo-allergenic and preservative and lactose free.

Sounds Great! Where Can I Buy Zylkene?

Zylkene can be bought from your vet's office and from all online pharmacies. Most online pharmacies have a next day delivery service.

At times, for stress, you might want to use prescription drugs from your vet's office, but these have to be prescribed by the vet and are known to have possible side effects. Zylkene is safe, over-the-counter, and can have spectacular results. You should definitely consider trying it out before shifting to prescription medications.


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      Carol 3 months ago

      My 11 yr old pitbull started getting anxious only at night time which was keeping me awake ALL NIGHT. My vet recommended Zylkene. I was skeptical because other prescription meds. , supplements or holistic remedies have not worked. Zylkene has so far. Thank you thank you thank you

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      Diane 11 months ago

      Have used it for a month on my yorkie - Cannot see ANY difference in her. Still hyper and still does not sleep at nite.

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      Julia 18 months ago

      my dog run away either go outside or run to the bedroom ugh still not helping

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      Joyce 18 months ago

      We had a house fire 2 months ago. Two of our three cats hunkered down in the fire area. My husband was successful in saving both. How ever Bonkers ran into the corn field. Two months later, he still would not enter our temporary home. Just started Zylkene last evening. This am he followed me in and has found himself a place to sleep. They say it doesn't work this fast..........but I'm giving it the credit!

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      Sandra 19 months ago

      I've given this product to my little 11 yo Maltese for a month since we live daily with thunderstorms this time of year and now have a hurricane coming our way. There's a big difference in her behavior since starting Zylkene. For minor rumbling thunderstorms, she doesn't shake or pant anymore, for more intense storms she may tremble but it's minor. For big loud lightening thunderstorms, she still shakes and trembles intermittently but her behavior overall has improved 90%. I'm keeping her on this medication until the storms are past since there appears to be no side effects. And will continue as needed. Our vet said she can be on it forever without incident. Good luck, for us it's a miracle in a capsule.

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      Norma 19 months ago

      Zylkene Dosage:

      Cat weighing less than 5Kg 1 x Zylkene 75mg Capsule daily

      Large Cat / Small dog weighing less than 10Kg 2 x Zylkene 75mg Capsules daily

      Dogs weighing between 10kg & 20Kg 1 x Zylkene 225mg Capsule daily

      Dogs weighing between 20Kg & 40Kg 1 x Zylkene 450mg Capsule daily

      Dogs weighing over 40Kg 2 x Zylkene 450mg Capsules daily

      Zylkene can be used short term or longer term:

      ♦ SHORT TERM: Zylkène supplementation should be started a few days before required. For example, several days before fireworks are anticipated or several days before the suitcase comes out for holiday packing.

      ♦ LONG TERM: Zylkène should be given for at least 1-2 months, if not longer. Examples include the arrival of a new baby.

      ♦ Stress is very common in both cats and dogs, and particularly in cats, but unfortunately often goes unnoticed. Whilst Zylkene is extremely helpful, it is important that it is used as part of a multifactorial approach to stress reduction. The environment has a huge impact on stress and anxiety in cats, and you will need to address this alongside using medications. In comparison, the owner has a larger effect than the environment in anxiety in dogs.

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      Norma 19 months ago

      I fostered a cat who was microchipped as a dog. He is too old to be rehomed and was terribly stressed by my other cats. I knew that I had to do something for him. The change was noticeable within a week. I thought I would have to keep him on Zylkene forever but that is not the case. Within two months, he was good to go. He still avoids the younger cats, but he now has no issues with them being in the same room anymore. I highly recommend Zylkene.

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      Nancy 23 months ago

      Why are there no answers to the above questions?? The answers would be very very helpful, as I have many of the same.

      Zylkene has worked well for moving our very anxious 12 yr old cat but after a few days now she's back to pacing through the new house, howling, wanting outside and ripping at the screens. Can I increase the 75 mg dose at all, even slightly? Or do I need to go back to the vet for something different? I thought this was 'the answer' but it seems to not be working any more (after just 5 days).

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      Irene cooper 2 years ago

      Can this be given per entry as my dog is 14 years old nearly.

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      Myra 2 years ago

      I have adopted a rescue cocker spaniel that weighs 18 lbs. her rescue mom sent her daily zylkene of 225 mg. The little cocker runs in circle in and out of the home. She is sweet and loveable. We have had her a short time and have noticed she is calming down. She sleeps good at night and seems almost OCD during the day! Hope it is only temporary with the help of these capsules, but seems more than she needs!

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      Kathy 2 years ago

      This article does not state what's in it. What are the ingredients?

      I wouldn't take anything for myself with knowing the ingredients much less my cat. I would be careful.

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      Angela 2 years ago

      I didn't really expect a natural product to work on my extremely anxious dog. 3 days after starting we had 6 hours of tornado alarms, thunderstorms, and general rushing around the house. All major triggers for him. He was amazingly calm. I mean it was so noticable. I'm happy not to have to go to xanex. Which was the next step. Hopeful he will quit being aggressive towards kids and digs now. ( yorkiepoo)

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      CJS1954 3 years ago

      I realize that Courtney's comment is 9 months old, but you need to have a full thyroid panel done on your dog. Low thyroid can be a sign of very bad aggression.

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      Jo 3 years ago

      So sorry for spelling the med wrong. It is Zylkene that I am giving to my Chihuahua. Thanks, again, for the very informative information on this med.


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      Jo 3 years ago

      Thank you so much for the information about Zyklene. Just began my little Chihuahua on these capsules as recommended by his Vet. I trust his Vet's good treatments and advice, but glad to learn more about Zyklene. I feel very comfortable about starting him on these caps after reading your Hub and other comments. Again, thank you so much for this information. Glad to know you are here..for further info, if needed.


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      courtney 4 years ago

      I was told to administer this along with my dogs usual dosage of reconcile...As soon as we combined the two, he became incredibly aggressive towards people, full on attacks...really sleepy and crying a lot..needless to say we stopped this medicine and are trying to get him back on track with the reconcile..if it becomes that his behavior is now permanent, he has to be put down.

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      Lily 4 years ago

      So I am not getting a clear answer from anyone including calling Vetoquil that makes Zyklene about how long term is long and if it's ok. I had my cat on it for a couple of months, noticed some improvement, took him off now back to being completely stressed out and spraying as well. Can they be on this permanently?!

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      Leica 4 years ago

      My dog is exactly on the cusp between the 225 and the 450mg dose, weight wise. Can I give him 225 in the morning and 75mg in the evening? What is the thinking behind the one-a-day administration?

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      kathy 5 years ago

      i just got zylkene for my little dog.this is her first day of it.i needed info on this drug so thank you i was worried about giving it to her im not now thanks


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      Paulart 6 years ago from 2510 Warren Avenue Cheyenne,Wyoming 82001

      Nice information is given on this hub.Thanks for sharing.