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How to Bond With Your Pet Mouse and Get It to Like You

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I love keeping pet mice and sharing care information with other rodent parents online.

Mice are naturally skittish, but can be conditioned to expect and enjoy human companionship.

Mice are naturally skittish, but can be conditioned to expect and enjoy human companionship.

How to Bond With Mice

Mice make great pets. They're easy to care for, intelligent, friendly, and amusing to watch. However, many new mouse owners take their pets home and quickly get disappointed or frustrated because they can't get the mouse to come out of their cage. In the wild, mice act as food for many predators. Contrary to what The Tale of Desperaux suggests, all the brave and courageous mice ended up as owl food long before they could pass on their genes.

While you have to deal with a timid, skittish creature, you can make him feel safe and friendly; otherwise, no one would keep mice as pets. Over the years, I've discovered the following techniques. Employing them on a regular basis will help get your pet accustomed to viewing you as its friendly, gigantic provider.

Mouse Taming Techniques

  1. Give them something comfortable that smells like you.
  2. Feed your mouse immediately after taking it out.
  3. Handle your mouse.
  4. Pick them up once they are familiar with you.
  5. Don't wear long sleeves when you handle your mouse.
  6. Play with them for 30 minutes per day.

1. Give Your Mouse Something Nice That Smells Like You

This method takes advantage of two instincts your mouse possesses: a fondness for warm, dark places and sensing the world through smell instead of sight. Mice don't have great eyesight, so they rely on their nose to orient them. While you (hopefully) can't detect your odor or that of the people around you, mice find it a distinguishing feature and identify who you are.

So, when you first bring him home, don't put anything in the cage they can hide in (except a toilet paper tube...I'll get to that later). Cut the toes off an old sock and wear it around your wrist for a day or two, then give it to the mouse. Without boxes, nooks, or tunnels, the sock will be the best material for a nest. He'll either crawl inside it or under it to feel safe, and he'll use it as a nest when he sleeps.

And it should smell like you. Therefore, he associates you with warmth, comfort, and safety simply because you smell like the sock.

I've used this technique often, but honestly, I wonder how effective it is. After two or three days, the mouse's smell will overpower your own. If you want to try this, remember to change the sock frequently--at the very least, throw it out every time you clean the cage. It gets gross.

2. Teach Your Mice to Associate You With Food

You can manipulate hunger to your advantage in two ways. The simplest one requires a bag of treats. Every time my mice come out to see me, I offer them a treat. They rarely eat it outside of the cage, so as soon as I put them back, I offer it to them. Make sure they see it immediately and take it from your hand. If you drop it in the cage and they find it an hour later, they won't associate treats with coming out to play.

I also read about a technique that requires nothing more than the bag of food you bought at the pet store. Pick out a bunch of the smallest seeds you can find. Then go a day without feeding your mouse. After 24 hours, put the seeds in your palm and hold your hand out in the cage. Don't move.

The mouse has to take the food from your hand. He'll probably swipe the seeds near the edge of your palm first, but seeds are small, and he'll have to come back for more. Place the bulk of the pile in the center. This will force the mouse to step on you with at least his front paws. Usually, he'll leave at least one paw on the bedding and do a sort of safety paw dance.

Let him dance if he wants to. Let him leave one paw behind. (I'm sorry...I couldn't resist) Give him the feeling that stepping onto his hand is safe and that he'll always have the option of going back to his nest.

While deer just stare at oncoming danger, mice can break the sound barrier in their dash for safety.

While deer just stare at oncoming danger, mice can break the sound barrier in their dash for safety.

3. Let Your Mouse Get Accustomed to Your Hands

Reach into the cage and try to grab the mouse, and he'll bounce off the walls to escape you. This sends him into a panic, and you probably won't have much luck. But stick your hand in there, palm up, and just wait, and you become an object of curiosity. Again, you rarely find a mouse who climbs completely into your hand and lets you pick him up, but if he sniffs around, your scent becomes familiar and non-threatening.

4. Pick Up Your Mouse and Handle Them

Nothing says "coming out to play won't kill you" better than coming out to play and not getting killed. So you'll have to pick him up at some point. Don't pick up the mouse by the tail, no matter who you've seen do it. Tails break easily. My girlfriend works with research animals and received training to know the proper place to lift from the tail. If you grab too far out, you could cause damage. I don't even risk it unless saving another mouse from a bully. (Pick up the bully, not the victim.)

That being said, the absolute best way to get a frightened mouse from the cage involves scaring him into a toilet paper tube. He should feel safe in a small, dark space, and you can just lift him, tube and all, out of the cage.

Don't shake him out into your hand. Place the tube as a bridge from one hand to the other. The mouse will inspect both ends. If he doesn't come out, start tilting the tube into one hand until the mouse either falls out of the bottom or backs his way up into your other hand.

5. Wear Short Sleeves When Handling Your Mouse

At first, you don't want to let the mouse run free on a table or bed or wherever (when you do, however, make sure you put him on an elevated surface that doesn't come close to anything he can jump across, climb to, or climb down). Let him use your arms (and your shirt, if you have a climber). Hold your arms across your chest, making a two-armed platform for him to run around on. It may not seem exciting, but it'll overwhelm the mouse at this point.

Push your inside hand (between the other arm and your chest) slightly underneath the other arm and cup your fingers. This gives the mouse a dark hidey-hole and lets him know it's safe to play on you.

Do all this without sleeves. He can smell you if he contacts your skin directly. Plus, it's easier to clean up.

6. Play With Your Mouse for 30 Minutes Every Day

Mice have a natural intelligence that makes them perfect research animals. However, they learn the same way as humans--through repetition. Play with them for at least 30 minutes a day. Take them out multiple times a day. Make sure they remember you. They'll learn, and eventually, you'll have trained a small, furry friend, and the fun will begin. Enjoy.

This article is accurate and true to the best of the author’s knowledge. It is not meant to substitute for diagnosis, prognosis, treatment, prescription, or formal and individualized advice from a veterinary medical professional. Animals exhibiting signs and symptoms of distress should be seen by a veterinarian immediately.


Lindsey Noll on March 21, 2020:

My mouse is wayyyy to scared for me to just grab her,and I’ve always picked her up by her tail, do you think I should stop doing that cause every time I do she squeaks and I thought it was just in fear but maybe it’s pain?

To sit in solemn silence on May 29, 2018:

To sit in solemn silence in a dull, dark, dock

In a pestilential prison with a life-long lock

Awaiting the sensation of a short, sharp, shock

From a cheap and chippy chopper on a big, black, block

A dull dark dock, a life long lock, and short sharp shock, a big black block.

NewMouseMom on May 17, 2018:

My new pet mouse bites me 2 and 3 times in one sitting, drawing blood! I laid my hand in his cage, with a treat on my upturned fingers or palm, the 1st time I did this he came readily into my palm, sniffed, then nudged between the base of my fingers, backed up a little and bit my finger and then my palm! No blood drawn.

The 2nd time I tried, he came readily onto my palm, took the treat, backed out and dropped the treat then came back onto my palm sat for a second or three then backed out quickly and bit my fingers...hard! The second bite drew blood. A LOT of blood!

He ran into his cocanut shell house afterward and I yanked my hand out!

So, he seemed afraid of me after he bit me but not before, what in the world do I do?

*I had an orphaned Mal baby (eyes open) that I tried to put him in with and he seemed very aggressive toward him so I separated them within 15 minutes by herding the 'pet store mouse' into a paper cup

Julia on January 08, 2018:

I have two little girl mice one pretty gray one (pidgeon) loved to come out and play from day one, but the black one (posie) is really hard to get iut amd wjen you do coax her onto your hand she just hides in your clothes untill you pit her back, i've tried a lot of these techniques but nothing works, is she just to shy?

Savannah on January 02, 2018:

I did the palm and treat thing to one of my female mice (Spice). She’s already walking all over me after 2 Days! Such a sweetheart. However, my Other female mouse (Sugar) is super mean and bites me because I am trying to get her to be more active. I am going to try the scent thing, but instead of a sock I’ll just give them a piece of fabric in the corner.

Jess on May 15, 2017:

I bought 2 mice about a week ago. I've never picked either up by the tail even though that's what the pet store fella did. It just seems cruel. Anyway I bought a pair and ended up with a bully and time out didn't work so I had to trade him out for the one I have now. He was straight up mean and brought blood on his supposed to be friend. I traded him out and my original gets along with the new one. I hated to trade him out since I had just "rescued" him from the pet store but nothing worked. Well, before I get carried away explaining unnecessary details I worked at slowly making friends with them both and now a week later they love to be held. I've not took them out to play or anything yet but they will let me hold them. I reach my hand in there and they don't run or try to flee and it's so awesome. I just added and extension to their enclosure and I am overcome with so much joy seeing them come out for their nightly play and discovering that they haven't just been moved to a new cage but instead had their home upgraded. It's very rewarding as strange as that sounds to be trusted by a tiny fearful animal. Patience is key with these little guys! I had a sock that was mate less so I cut the toe out and used safety pins to attach it to each side of the cage in a corner and they love it. It's up off the ground so no mess or nasty and they don't potty where they sleep so it's kept fairly clean. They love it! I found the idea on youtube under a search for snuggle pouch hammock for a mouse. They love it. Sorry for the length I'm just thrilled my mice are coming out of their "shell" and thought I'd share my experience so far. Patience with mice pay off in the long run, Big time!!

Pip and Pepper the Mice on September 27, 2016:

Hi! I have 2 female mice, and their names are Pip and Pepper. Pepper is very bold, and I tamed her in just 4 days. Pip, on the other paw, is extremely shy and whenever she even sees me walk by, she runs into her house. Pip also has a little bend in her tail, possibly from when she was bred. Maybe she had been abused and now she is scared of everything. I am about to start trick mousing with Pepper but I would like Pip on the same page. How do I get her to be less afraid of me?

Sarah on May 07, 2016:

My mouse is extremely timid and won't sit on my. She actually just climbs up me to get a higher point to jump off. And she jumps like CRAZY. I only handle her while sitting in the bathtub because otherwise she just jumps right off me and I have to try find her. She isn't eating either. HELLLPPP my mouse is crazy

holly on March 05, 2016:

I have a mouse called ruby and another called coco.ruby seems really scared of me. I let her run around me and I picked her up by her tail and I didn't catch her and I feel really bad. she got scared and I don't know how to overcome the timid Ness in her

jplaj (author) from Duluth, MN on March 29, 2015:


That's normal. When moving to a new cage/location/owner, mice are under a lot of stress and will often act differently once they've settled in. Just keep at it, follow the tips here, and the more you handle them, the more they'll want to come out.

cassie on March 29, 2015:

I just got three new baby mice yesterday, and for the first hours of playing they were really nice and lovely. They were so friendly and liked to run on your hand the second you open the door. After I came home later a night after a family get together, they no longer seemed to like me. They just ran away and hid. I don't know what happened.

uttara on March 28, 2015:

Awesome tips....

KayTeh on January 31, 2013:

Thank you so much!! I just got two little girl mice yesterday and my mom is already threatening to give them away. They kept us up all night last night being very noisy with their food and clicky water bottle, and then they have slept all day so far today. I want to be able to play with them, and help my mom to see that they aren't pests. I'm definitely gonna try this with them today or tomorrow. Thank you so much!!

Luke flack on June 09, 2012:

Just got one won't come out but is going to try this methods. Thank you!! Love the mouse!!

jplaj (author) from Duluth, MN on June 06, 2012:

Bekkii, for starters, don't get discouraged. Mice are easily frightened, but that doesn't necessarily mean they're hurt. Give him time and try giving him some soft fabric that smells like you. Don't make sudden movements. Let him warm up to you for a while. After a few days, try taking him out. Buy work gloves if you're afraid he'll bite you. Give him some place fun to play that's not on you. Stay nearby, though, to let him get used to you, and when you put him back, give him a treat.

The idea is to make him associate coming out of the cage with enjoyment. Some mice take longer than others to warm up to you, but be patient and try not to get frustrated or discouraged.

Thanks for reading.

Bekkii on June 06, 2012:

i brought a mouse, i'd never owned one before. The place told me to handle it by the tail. For the first couple of days i just lay my hand in the cage and let him sniff me if he wanted. the i tired feeding him food but he wouldn't take it. he finally started comeing closer so i lifted him out (by the tail stupidly as the pet place told me to) he started squeeking going mad so i lay him on my hand and he bit me and i was pouring with blood. now my mouse wont come near me at all and earlier it ran past my hand and bumped of me so it squeeked and hid. i don't know how to try and get him to trust me again.

Mermaid on April 27, 2012:

Thank you ! I might be getting mice tomorrow too ! This helps

may hodgkinson on March 29, 2012:

I'm getting a mouse tomorrow and this was just the info I needed. Thank You!!!

Marco Alvarado on November 09, 2011:

my mouse likes me now

Sneha Sunny from India on September 08, 2011:

wow.... those were nice tips..... and cute mouse